Microplastics Found in Human Ovary Follicular Fluid for the First Time
Tom Perkins | The Guardian | April 19, 2025
Microplastics have been found for the first time in human ovary follicular fluid, raising a new round of questions about the ubiquitous and toxic substances’ potential impact on women’s fertility.
The new peer-reviewed research published in Ecotoxicology and Environmental Safety checked for microplastics in the follicular fluid of 18 women undergoing assisted reproductive treatment at a fertility clinic in Salerno, Italy, and detected them in 14.
Follicular fluid provides essential nutrients and biochemical signals for developing eggs. Contaminating that process with bits of plastic quite likely has implications for fertility, hormonal balance and overall reproductive health, the authors wrote.
The findings represent a major step toward figuring out how and why microplastics impact women’s reproductive health, but are also “very alarming”, Luigi Montano, a researcher at the University of Rome and study lead author, said.
“This discovery should serve as an important warning signal about the invasiveness of these emerging contaminants in the female reproductive system,” the study states.
From the top of Mt Everest to the bottom of the Mariana Trench, microplastics and smaller nanoplastics have been detected throughout the environment. Food is thought to be a main exposure route: recent studies found them in all meat and produce products tested.
Microplastics are particularly dangerous because they can contain any number of 16,000 plastic chemicals. That includes highly toxic compounds like Pfas, bisphenol and phthalates, which are linked to cancer, neurotoxicity, hormone disruption and developmental toxicity.
Microplastics have been found throughout the human body and can cross the brain and placental barriers.
Montano’s latest paper is part of a larger project he’s leading for which he has also detected microplastics in human urine and semen, and examines the impacts on fertility. He said he suspects microplastics are among chemicals driving plummeting sperm counts and a drop in overall sperm quality.
“We have proven this decline, especially in areas where pollution is bad,” Montano said.
Though men are more susceptible to the substance’s toxic effects, he added, women are also possibly impacted. Animal research has linked the presence of microplastics to ovarian dysfunction and health problems, like reduced oocyte maturation, and a lower capacity for fertilization. Another study on mice showed alterations to ovarian tissue.
The paper notes a “possible presence of correlation between the concentration of microplastics” and reproductive health in the women who participated in the new study.
